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Occlusive hydrocolloid dressings decrease keratinocyte population growth fraction and clinical scale and skin
A B Gottlieb1, L Staiano-Coico, S R Cohen
1Laboratory for Investigative Dermatology, Rockefeller University, New York, NY 10021.
Journal of Dermatological Science
|March 1, 1990
Summary
Occlusion therapy significantly reduces psoriasis symptoms like scale and skin thickness within two weeks. This method also decreases keratinocyte growth fraction, indicating a synergistic role in managing psoriatic plaques.
Area of Science:
- Dermatology
- Cell Biology
Background:
- Clinical studies indicate occlusion may treat psoriasis.
- Previous research showed increased keratinocyte growth fraction in psoriatic plaques, which normalized with treatment.
Purpose of the Study:
- To evaluate the efficacy of occlusion in treating psoriatic plaques.
- To assess changes in clinical parameters and keratinocyte growth fraction.
Main Methods:
- Nine patients with psoriasis were included.
- Occlusion was applied to one plaque, with a control plaque for comparison.
- Clinical assessments (scale, thickness, erythema) and RNA/DNA flow cytometry were used.
Main Results:
- Occlusion reduced scale and skin thickness within two weeks.
- No further significant changes were observed after ten weeks.
- Keratinocyte growth fraction significantly decreased in occluded plaques after ten weeks.
Conclusions:
- Occlusion therapy shows early benefits in reducing psoriatic plaque severity.
- Occlusion therapy synergistically enhances other treatment modalities for psoriasis.