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Related Experiment Videos

Urticarial reaction caused by ethanol.

Yukinobu Nakagawa1, Yasuyuki Sumikawa, Toshiaki Nakamura

  • 1Osaka Kouseinenkin Hospital, Osaka-city, Japan. buntyo@okn.gr.jp

Allergology International : Official Journal of the Japanese Society of Allergology
|November 30, 2006
PubMed
Summary

A patient experienced alcohol-induced urticaria, with tests revealing a positive reaction to acetic acid, a key alcohol metabolite. This suggests alcohol intolerance may trigger such reactions, though acetaldehyde allergy is also possible.

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Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • Presents a case study of a 47-year-old male experiencing recurrent urticarial and anaphylactoid reactions to alcohol beverages over two years.
  • Highlights the consistent nature of these adverse reactions following every alcohol intake.

Observation:

  • Diagnostic testing included prick tests with ethanol, alcohol beverages, and metabolites (acetaldehyde, acetic acid).
  • A positive prick test result was observed exclusively with acetic acid.
  • Oral challenge tests with diluted ethanol and Shochu induced dose-dependent symptoms like pruritus, lip swelling, and wheals.

Findings:

  • Acetic acid, an alcohol metabolite, was the sole positive trigger in prick testing for this patient.
  • The patient exhibited a positive wheal reaction to diluted alcohol and Shochu during oral challenge tests.

Related Experiment Videos

  • These findings suggest alcohol intolerance as a potential cause of urticaria in this individual.

    • Implications:

    • This case highlights acetic acid as a potential trigger for alcohol-induced urticaria.
    • The results differentiate this reaction from typical allergic responses, pointing towards metabolic intolerance.
    • Further investigation into acetaldehyde's role is warranted to fully elucidate the mechanisms of alcohol hypersensitivity.