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Enterobius vermicularis and colitis in Children
Michelle Jardine1, George K Kokai, A Mark Dalzell
1Department of Paediatric Gastroenterology, The Royal Liverpool Children's NHS Trust, Liverpool, UK.
Insights
Enterobius vermicularis (pinworm) infestation can cause nonspecific colitis in children. Colonoscopy is effective for diagnosis, while conventional tests like saline swabs and Sellotape tests may lack sensitivity for pinworm detection.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Diagnostic Accuracy
Background:
- Enterobius vermicularis (pinworm) infestation is common in children.
- Rectal bleeding and abdominal pain are common presenting symptoms.
- Conventional diagnostic methods for pinworm infestation may have limitations.
Purpose of the Study:
- To evaluate the reliability of diagnostic methods for Enterobius vermicularis (pinworm) infestation in children presenting with rectal bleeding.
- To assess the association between pinworm infestation and nonspecific colitis.
Main Methods:
- Retrospective cohort study of children undergoing colonoscopy.
- Direct visualization of adult Enterobius vermicularis (pinworm) during colonoscopy for diagnosis.
- Clinical response to mebendazole treatment was documented.
Main Results:
- Enterobius vermicularis (pinworm) was identified in 17.2% of colonoscopies.
- Symptoms included abdominal pain (73%), rectal bleeding (62%), chronic diarrhea (50%), and weight loss (42%).
- Nonspecific colitis was present in 81% of children with pinworm infestation; conventional tests were largely negative.
Conclusions:
- Enterobius vermicularis (pinworm) infestation should be considered in children with symptoms suggestive of inflammatory bowel disease and nonspecific colitis.
- Colonoscopy is a reliable method for diagnosing pinworm infestation.
- Saline swabs and Sellotape testing may lack sensitivity for detecting pinworm infestation.
Objectives:
We observed a cohort of children presenting with rectal bleeding that were identified as having Enterobius vermicularis at colonoscopy and questioned the reliability of conventional diagnostic methods of identifying E. vermicularis.
Patients And Methods:
The study was retrospective in nature and subjects were investigated by colonoscopy between May 1997 and December 1999. Patients were identified as having E. vermicularis infestation by direct visualisation of the adult worms at colonoscopy. Patients were treated with mebendazole and a record of their clinical response documented.
Results:
A total of 180 colonoscopic examinations were performed during the study period. E. vermicularis was identified macroscopically in 31 cases (17.2%). The symptom profile of patients with E. vermicularis were abdominal pain, 19 of 26 (73%); rectal bleeding, 16 of 26 (62%); chronic diarrhoea, 13 of 26 (50%) and weight loss, 11 of 26 (42%). Ova cysts and parasites were identified in none of the saline swabs analysed in 20 patients. Sellotape testing was performed in only 4 patients and was negative in all. Of the 26 children, 21 (81%) demonstrated histopathological features of nonspecific colitis. There was clinical resolution of symptoms in 19 of 23 patients.
Conclusions:
We suggest that in patients with symptoms suggestive of inflammatory bowel disease, E. vermicularis infestation must be excluded as a common cause of nonspecific colitis. We also suggest that diagnostic tests such as saline swabs and Sellotape testing may be lacking in sensitivity.
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