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Published on: November 14, 2018
Using intranasal lidocaine to reduce food intake
F L Greenway1, C K Martin, A K Gupta
1Outpatient Clinic Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. greenwfl@pbrc.edu
International Journal of Obesity (2005)
|November 30, 2006
Summary
Intranasal lidocaine reduced hunger and desire to eat in obese subjects, but did not significantly decrease food intake. This suggests intranasal lidocaine is unlikely to be effective for obesity treatment.
Area of Science:
- Pharmacology
- Obesity Research
- Gastroenterology
Background:
- Obesity is a complex metabolic disorder with significant public health implications.
- Appetite regulation is a key target for weight management interventions.
- Intranasal drug delivery offers a potential route for systemic or localized effects.
Purpose of the Study:
- To establish a dose-response relationship for intranasal lidocaine's effect on food consumption.
- To evaluate the impact of varying doses of intranasal lidocaine on appetite-related sensations.
Main Methods:
- A double-blind, placebo-controlled, four-period crossover study was conducted.
- Healthy obese subjects received saline or 2.5, 10, or 25 mg of intranasal lidocaine before a meal.
- Food intake, hunger, desire to eat, craving, and fullness were measured; safety was monitored via vital signs and lab tests.
Main Results:
- No statistically significant reduction in food intake was observed across the tested lidocaine doses compared to saline.
- A dose-dependent decrease in hunger and desire to eat was noted, particularly at the 25 mg dose (P<0.03).
- No significant adverse events or safety concerns were identified.
Conclusions:
- Intranasal lidocaine effectively reduced subjective feelings of hunger and desire to eat.
- The observed reduction in appetite sensations did not lead to a significant decrease in actual food consumption.
- Intranasal lidocaine is unlikely to be a viable therapeutic agent for the management of obesity.
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