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Updated: Jul 18, 2026
09:02
Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
The cold case: are rhinoviruses perfectly adapted pathogens?
S Dreschers1, C A Dumitru, C Adams
1Dept of Molecular Biology, University of Duisburg-Essen, Hufelandstr 55, 45122, Essen, Germany. stephan.dreschers@uni-essen.de
Cellular and Molecular Life Sciences : CMLS
|November 30, 2006
Summary
Rhinoviruses, the cause of the common cold, are diverse viruses that infect humans. This review summarizes rhinoviral infections and explores therapeutic strategies against this adaptable pathogen.
Area of Science:
- Virology
- Immunology
Background:
- Rhinoviruses are small, non-enveloped viruses belonging to the Picornaviridae family, with over 100 identified serotypes.
- They possess a single-stranded RNA genome and are classified into major and minor groups based on receptor binding (ICAM-1 or VLDL receptors).
- Viral entry involves conformational changes in the capsid upon receptor interaction, triggering chemokine responses that can exacerbate cold symptoms like asthma and inflammation.
Purpose of the Study:
- To provide a comprehensive overview of current knowledge regarding rhinoviral infections.
- To discuss emerging and established therapeutic approaches targeting rhinoviruses.
Main Methods:
- This review synthesizes existing scientific literature on rhinoviruses.
- It analyzes data on viral structure, replication, host interactions, and clinical manifestations.
- Therapeutic strategies are evaluated based on their mechanisms of action and potential efficacy.
Main Results:
- Rhinoviruses are the most diverse picornavirus group, with over 100 serotypes.
- Viral attachment and entry mechanisms are well-defined, involving specific host cell receptors.
- Infection elicits immune responses, contributing to common cold symptoms and exacerbation of conditions like asthma.
Conclusions:
- Understanding rhinoviral diversity and host interactions is crucial for developing effective treatments.
- Targeting viral entry or host responses presents viable therapeutic avenues.
- Further research into novel therapeutic strategies is needed to combat this persistent pathogen.
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