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[Lennert's lymphoma and glomerulonephritis].
R Munker1, W Nathrath, W Permanetter
1Medizinische Klinik III, Universität München.
Deutsche Medizinische Wochenschrift (1946)
|July 26, 1991
Summary
A patient with lymphoepithelial lymphoma developed kidney problems, possibly due to the cancer. Despite initial chemotherapy success, the lymphoma recurred, leading to terminal renal failure.
Area of Science:
- Oncology
- Nephrology
- Pathology
Background:
- Lymphoepithelial lymphoma, a T-cell lymphoma, can present with varied clinical manifestations.
- Paraneoplastic syndromes can affect multiple organ systems, including the kidneys.
Observation:
- A 49-year-old man presented with a neck swelling diagnosed as chronic lymphadenitis.
- He subsequently developed leg edema, proteinuria, and elevated creatinine, indicative of glomerulonephritis.
- Imaging revealed a parotid-region mass, histologically confirmed as lymphoepithelial lymphoma (Lennert's lymphoma).
Findings:
- The patient achieved remission with chemotherapy (COPP schedule) but experienced tumor recurrence.
- Renal function initially improved post-chemotherapy but ultimately deteriorated.
- Terminal renal failure developed four years after initial lymphoma diagnosis.
Implications:
- This case highlights the potential for lymphoepithelial lymphoma to induce paraneoplastic glomerulonephritis.
- The interplay between T-cell lymphoma and renal pathology warrants further investigation.
- Understanding paraneoplastic phenomena is crucial for managing complex oncological and nephrological cases.