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Related Experiment Videos

Elenoside increases intestinal motility.

E Navarro1, S-J Alonso, R Navarro

  • 1Department of Pharmacology, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Apdo. 55, Tenerife, Canary Islands, Spain. enavarro@ull.es

World Journal of Gastroenterology
|November 30, 2006
PubMed
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Elenoside, a compound from Justicia hyssopifolia, enhances gastrointestinal motility in rats, acting similarly to prokinetic drugs like cisapride. This suggests its potential for treating gastrointestinal disorders and mitigating opioid-induced side effects.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Natural Products Chemistry

Background:

  • Gastrointestinal motility disorders affect millions globally, necessitating novel therapeutic agents.
  • Opioid analgesics often cause significant gastrointestinal side effects, including constipation.
  • Plant-derived compounds are a rich source for discovering new drugs with diverse pharmacological activities.

Purpose of the Study:

  • To investigate the gastrointestinal prokinetic and laxative effects of elenoside, an arylnaphthalene lignan isolated from Justicia hyssopifolia.
  • To compare the effects of elenoside with known prokinetic (cisapride) and constipating (codeine phosphate) agents in preclinical models.
  • To evaluate the efficacy of elenoside both in vivo and in vitro using rat models.

Main Methods:

Related Experiment Videos

  • In vivo studies involved assessing catharsis index, bolus water content, and intestinal transit in rats treated with elenoside, cisapride, or codeine phosphate.
  • In vitro experiments utilized isolated rat intestinal tissues (duodenum, jejunum, ileum) to analyze the effects of elenoside and cisapride on tissue contractility.
  • Dose-response relationships and antagonism studies were conducted to characterize elenoside's pharmacological actions.

    • Main Results:

    • Elenoside administration in vivo significantly increased the catharsis index, bolus water percentage, and intestinal transit.
    • Codeine phosphate was found to antagonize the effects of elenoside at a specific dosage.
    • In vitro, elenoside modulated intestinal tissue contractions and decreased intestinal frequency, with effects mirroring those of cisapride.

    Conclusions:

    • Elenoside exhibits both purgative and prokinetic properties, acting similarly to established drugs in this class.
    • The findings suggest that elenoside could serve as a viable alternative to cisapride for managing gastrointestinal diseases.
    • Elenoside presents potential as a preventive therapy for opioid-induced gastrointestinal dysfunction.