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Updated: Jan 1, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Blood management in total joint arthroplasty
Hari R Bezwada1, David G Nazarian, David H Henry
1Balderston Orthopaedics, Pennsylvania Hospital, 800 Spruce St., Philadelphia, PA 19107, USA. hbezwada@yahoo.com
Managing substantial blood loss during total joint arthroplasty is crucial. This review covers blood management techniques and the risks of perioperative anemia and transfusion complications.
Area of Science:
- Orthopedic Surgery
- Anesthesiology
- Transfusion Medicine
Background:
- Total joint arthroplasty (TJA) is frequently associated with significant perioperative blood loss.
- Uncontrolled hemorrhage can lead to serious complications and increased patient morbidity.
- Effective blood management strategies are essential for optimizing patient outcomes in TJA.
Purpose of the Study:
- To review current techniques for managing perioperative blood loss in TJA.
- To discuss the clinical consequences of perioperative anemia.
- To outline potential problems associated with allogeneic blood transfusions.
Main Methods:
- Literature review of established and emerging blood management strategies.
- Analysis of the physiological effects and clinical impact of perioperative anemia.
- Examination of transfusion-related adverse events.
Main Results:
- Multiple blood management strategies exist, including autologous donation, pharmacologic agents, hemodilution, and cell salvage.
- Perioperative anemia can negatively impact recovery and increase the risk of complications.
- Allogeneic blood transfusions carry inherent risks that must be considered.
Conclusions:
- A multimodal approach to blood management is recommended for TJA patients.
- Minimizing blood loss and managing anemia are critical for patient safety and recovery.
- Careful consideration of transfusion risks versus benefits is necessary.
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