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Statins and progression of calcified aortic stenosis

Doson Chua1, Kelli Kalb

  • 1St. Paul's Hospital, Vancouver, BC, Canada. dchua@providencehealth.bc.ca

The Annals of Pharmacotherapy
|November 30, 2006
PubMed

Insights

Statins showed a potential to slow aortic stenosis (AS) progression in retrospective studies, but conflicting results from prospective trials mean they are not currently recommended for AS treatment.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Aortic stenosis (AS) is a progressive cardiovascular disease.
  • Statins are lipid-lowering drugs with potential anti-inflammatory and plaque-stabilizing effects.

Observation:

  • This review synthesized evidence from 7 studies (2 prospective, 5 retrospective) on statin efficacy in reducing calcified AS progression.
  • Retrospective studies suggested statins delay AS progression.

Findings:

  • One prospective observational trial indicated benefit, but a large randomized trial found no significant effect of statins on AS progression.
  • Conflicting results emerged between retrospective and prospective study designs.

Implications:

  • Current evidence is insufficient to recommend statins for treating aortic stenosis.
  • Larger, well-designed clinical trials are needed to clarify the role of statins in AS management.
Abstract

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