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Related Concept Videos

Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

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Stem cell plasticity: the debate begins to clarify.

Alexandros Spyridonidis1, Robert Zeiser, Marie Follo

  • 1Freiburg University Medical Center, Department of Hematology/Oncology, Hugstetter Strasse 55, Freiburg, Germany. spyridonidis@mm11.ukl.uni-freiberg.de

Stem Cell Reviews
|November 30, 2006
PubMed
Summary

The plasticity of adult stem cells is debated, with research exploring their potential to regenerate organs and aid gene therapy. This review examines the evidence, mechanisms, and clinical significance of stem cell plasticity.

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Last Updated: Jul 18, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Published on: June 10, 2018

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
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Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Ancient Greeks recognized regenerative powers in Hydra and human liver.
  • Hematopoietic stem cells in bone marrow exemplify adult stem cells.
  • Recent findings suggest bone marrow cells may contribute to non-hematopoietic organs, challenging previous understanding.

Purpose of the Study:

  • To review the current status of the adult stem cell plasticity debate.
  • To present data on detection methodology, mechanisms, and implications.
  • To discuss the clinical significance of stem cell plasticity in organ regeneration and gene therapy.

Main Methods:

  • Literature review of studies on adult stem cell plasticity.
  • Analysis of data on detection methodologies.
  • Examination of underlying mechanisms and physiological implications.

Main Results:

  • A significant debate exists regarding the plasticity of adult stem cells.
  • Conflicting results have been reported, fueling public and political discussion.
  • Evidence is presented on detection methods, mechanisms, and clinical relevance.

Conclusions:

  • The plasticity of adult stem cells remains a complex and debated topic.
  • Understanding stem cell plasticity is crucial for advancements in regenerative medicine and gene therapy.
  • Further research is needed to clarify the full potential and limitations of adult stem cells.