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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Maintenance of the ES Cell State

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Related Experiment Video

Updated: Jul 18, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

Stem cell plasticity: a rare cell, not a rare event.

Yoon-Young Jang¹, Saul J Sharkis

¹Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Stem Cell Reviews

|November 30, 2006

Summary

Investigating stem cell (SC) plasticity requires pure cell populations. Understanding how environmental cues and gene regulation influence SC fate determination is crucial for regenerative medicine applications.

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Area of Science:

Stem cell biology
Regenerative medicine
Cellular plasticity

Background:

Purifying rare stem cell (SC) populations by function and phenotype is essential for studying cell fate changes (plasticity).
Cell fate is influenced by both external environmental cues and intrinsic gene regulation.
Variations in SC plasticity may stem from different isolation methods or developmental stages.

Purpose of the Study:

To establish prerequisites for studying stem cell plasticity.
To investigate the roles of environmental cues and gene regulation in cell fate determination.
To explore the potential origins and functions of tissue-specific and primitive marrow SCs.

Main Methods:

Homogeneous purification of rare stem cell populations.
Analysis of stem cell function and phenotype.
Investigating the impact of environmental cues and gene regulation on stem cell plasticity.

Main Results:

Homogeneous stem cell purification is a prerequisite for plasticity studies.
Both external and internal factors influence stem cell fate determination.
Different isolation techniques or developmental stages may affect marrow SC plasticity.

Conclusions:

Understanding stem cell plasticity is key to regenerative medicine.
Dissecting the relationship between primitive/tissue-specific SCs and regenerative signals is important.
Further research is needed to fully elucidate stem cell behavior and therapeutic potential.