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Human immunodeficiency virus type 1 infection of endothelial cells in vitro
M C Re1, G Furlini, G Cenacchi
1Institute of Microbiology, University of Bologna, S. Orsola Hospital, Italy.
Microbiologica
|April 1, 1991
Abstract:
In order to establish whether endothelial cells are involved in immunodeficiency virus type 1 (HIV-1) infection, we performed a virological study on endothelial cells isolated from human adipose tissue and infected with HIV-1 in vitro. Supernatants from cultures showed a reverse transcriptase activity starting one day after HIV inoculation. Viral rescue was significantly impaired in cycloheximide treated cells confirming a de novo synthesis of viral products.