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Pseudophakic corneal edema: A review of mechanisms and treatments

Raja Narayanan1, Ronald N Gaster, M Cristina Kenney

  • 1LV Prasad Eye Institute, Banjara Hills, Hyderabad, India.

Cornea
|November 30, 2006
PubMed
Abstract

Insights

Pseudophakic corneal edema (PCE) is a common complication. While treatments are improving, penetrating keratoplasty remains the most effective solution for this condition.

Area of Science:

  • Ophthalmology
  • Corneal Science
  • Pathology

Background:

  • Pseudophakic corneal edema (PCE) is a significant complication following intraocular lens implantation.
  • It is a leading indication for penetrating keratoplasty, a corneal transplant procedure.

Purpose of the Study:

  • To review the pathological mechanisms underlying PCE.
  • To examine current and potential treatments for pseudophakic corneal edema.

Main Methods:

  • Literature review focusing on molecular biology of PCE.
  • Analysis of surgical and medical treatment strategies for PCE.

Main Results:

  • Decreasing incidence of PCE due to improved surgical techniques and intraocular lens designs.
  • Abnormalities in extracellular matrix and growth factors are implicated in PCE.
  • The role of aquaporins in fluid regulation in PCE corneas is under investigation.

Conclusions:

  • While novel treatments are emerging, penetrating keratoplasty remains the gold standard for treating PCE.
  • Penetrating keratoplasty offers the highest success rate for managing pseudophakic corneal edema.

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