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Human papilloma virus in hyperplastic tonsillar and adenoid tissues in children

Ioannis N Mammas1, George Sourvinos, Catherine Michael

  • 1Laboratory of Virology, School of Medicine, University of Crete, Heraklion, Greece.

The Pediatric Infectious Disease Journal
|November 30, 2006
PubMed

Insights

Human papillomavirus (HPV) DNA was found in 8.5% of children with tonsillar and adenoid hyperplasia. The study highlights the need for cautious evaluation of high-risk HPV DNA detection in pediatric cases.

Area of Science:

  • Pediatric Otolaryngology
  • Viral Oncology
  • Molecular Diagnostics

Background:

  • Childhood human papillomavirus (HPV) infections cause various conditions, including skin/anogenital warts and recurrent respiratory papillomatosis.
  • Limited data exists on HPV prevalence in pediatric tonsillar and adenoid hyperplasia.

Purpose of the Study:

  • To determine the presence of HPV DNA in children diagnosed with benign tonsillar and/or adenoid hyperplasia.

Main Methods:

  • Polymerase chain reaction (PCR) with general GP5+/GP6+ primers was used to test 106 tissue samples from 102 children (ages 2-14).
  • Specific PCR primers were employed for HPV typing (HPV-16, -18, -33, -11).

Main Results:

  • HPV DNA was detected in 9 (8.5%) of the specimens.
  • HPV-16 was the most frequent type (66.7%), followed by HPV-11 (22.2%).
  • HPV was found in both tonsillar (9.4%) and adenoid (7.1%) hyperplasia cases, with a lower mean age in HPV-positive children.

Conclusions:

  • The clinical significance of HPV DNA in tonsillar and adenoid hyperplasia requires further investigation.
  • Detection of high-risk HPV DNA in these pediatric conditions warrants careful consideration.
Abstract

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