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Amebiasis

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Cryptococcal Meningitis

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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

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Giardiasis

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Updated: Jul 18, 2026

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

Human immunodeficiency virus infection and amebiasis.

Douglas M Bowley¹, Jerome Loveland, Tanvier Omar

¹Division of Paediatric Surgery, University of Witwatersrand, Johannesburg, South Africa. dougbowley@aol.com

The Pediatric Infectious Disease Journal

|November 30, 2006

Summary

Pediatric HIV infection is a growing global concern, especially in sub-Saharan Africa. Recent data suggest amebiasis may pose a significant risk to individuals with HIV/AIDS.

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Area of Science:

Infectious Diseases
Immunology
Global Health

Background:

Pediatric HIV infection presents a substantial and increasing global health challenge, disproportionately affecting sub-Saharan Africa.
Coinfection with pathogens accelerates HIV/AIDS progression, while disease-induced immunosuppression heightens susceptibility to opportunistic infections.

Observation:

Despite the high prevalence of HIV/AIDS, amebiasis has not been widely recognized as a primary cause of illness in affected children.
Emerging evidence indicates a potential link between amebiasis and increased morbidity in individuals with HIV/AIDS.

Findings:

Recent information suggests that amebiasis could represent an underappreciated risk factor for individuals living with HIV/AIDS.
Further research is needed to fully elucidate the relationship between amebiasis and HIV/AIDS progression and severity.

Implications:

These findings highlight the importance of considering amebiasis in the differential diagnosis of opportunistic infections in pediatric HIV patients.
Increased awareness and diagnostic vigilance for amebiasis may improve clinical outcomes for children with HIV/AIDS in high-prevalence regions.