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Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome

Michelle N Gong1, Wei Zhou, Paige L Williams

  • 1Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

Critical Care Medicine
|November 30, 2006
PubMed
Abstract

Insights

The mannose binding lectin-2 (MBL-2) codon 54BB genotype is linked to higher acute respiratory distress syndrome (ARDS) risk and mortality. This finding may inform ARDS susceptibility and outcome predictions.

Area of Science:

  • Immunogenetics
  • Critical Care Medicine
  • Molecular Biology

Background:

  • Mannose binding lectin-2 (MBL-2) gene variants are associated with MBL deficiency and sepsis susceptibility.
  • Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition with significant mortality.
  • The role of MBL-2 genotypes in ARDS pathogenesis and outcomes requires further investigation.

Purpose of the Study:

  • To investigate the association between variant MBL-2 genotypes and susceptibility to ARDS.
  • To determine if MBL-2 genotypes influence the severity and mortality of ARDS.

Main Methods:

  • A nested case-control study was conducted at a tertiary academic medical center.
  • Genotyping for variant alleles (X, D, B, C) of MBL-2 codons -221, 52, 54, and 57 was performed.
  • Two hundred and twelve Caucasians with ARDS and 442 controls were analyzed.

Main Results:

  • The MBL-2 codon 54BB genotype was associated with increased ARDS risk (adjusted OR, 6.7) and higher mortality (adjusted HR, 4.0) in patients.
  • Patients with the 54BB genotype exhibited greater illness severity and a higher likelihood of septic shock.
  • No significant associations were found for variant alleles at codons -221, 52, and 57 due to low allele frequencies.

Conclusions:

  • The MBL-2 codon 54BB genotype may play a significant role in ARDS susceptibility and patient outcomes.
  • Further research is warranted to validate these findings in diverse populations.
  • MBL-2 genotyping could potentially aid in predicting ARDS risk and prognosis.

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