Related Experiment Video
Updated: Jul 18, 2026
19:57
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
A practical method to calibrate self-reported adherence to antiretroviral therapy
Honghu Liu1, Loren G Miller, Ron D Hays
1Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095-1736, USA. hhliu@ucla.edu
Journal of Acquired Immune Deficiency Syndromes (1999)
|November 30, 2006
Summary
Calibrating self-reported antiretroviral adherence with objective measures and patient attitudes improves accuracy. This enhanced method better detects nonadherence in HIV treatment.
Area of Science:
- Medical Research
- Public Health
- HIV/AIDS Treatment
Background:
- Self-reported adherence to antiretroviral medications is a common but often inaccurate measure.
- Existing methods overestimate patient adherence, potentially impacting treatment outcomes.
Purpose of the Study:
- To develop a more accurate self-reported adherence measure by calibrating self-reports with objective data.
- To identify attitudinal factors influencing the discrepancy between self-reported and objectively measured adherence.
Main Methods:
- Longitudinal cohort design using data from 330 patients across 5 HIV clinics.
- Examined discrepancies between self-reported and objectively measured adherence.
- Evaluated the relationship between attitudinal measures and adherence discrepancies, using cross-validation to refine survey items.
Main Results:
- Self-reported adherence was consistently higher than objectively measured adherence.
- Optimal calibration models incorporated self-reported adherence, regimen duration, and specific attitudinal factors.
- Attitudinal factors included perceived ease of medication use, belief in medication efficacy, and perceived treatment burden.
Conclusions:
- A calibrated self-report measure can more accurately approximate objectively measured adherence.
- The enhanced measure demonstrates improved sensitivity in detecting nonadherence.
- These findings suggest a more reliable tool for monitoring HIV treatment adherence in clinical settings.
