Related Experiment Video
Updated: Jul 18, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
[Influence of selected Lactobacillus sp. on Clostridium difficile strains with different toxigenicity profile]
Dorota Wultańska1, Hanna Pituch, Piotr Obuch-Woszczatyński
1Katedra i Zakład Mikrobiologii Lekarskiej AM w Warszawie.
Abstract:
This study was performed for determination of antagonistic activity of Lactobacillus spp. (L. plantarum 2017405, L. rhamnosus GG, L. acidophilus DSM 21007 and L. fernmentumn 353) on Clostridiunl difficile strains belonging to different toxigenicity profiles. Forty strains C. difficile isolated from patients suffering from antibiotic associated diarrhea (AAD) were used. Among C. difficile strains 13 produced toxin A and B (A+B+CDT-), 14 produced only toxin B (AB'CDT), 9 produced toxins A and B and possessing of binary toxin genes (A+B+CDT-) and 4 were non-toxigenic (A-B-CDT-). We did not observe relationship between degree of antagonistic activity Lactobacillus spp. and profile of toxigenicity of C. difficile strains.
Related Concept Videos
Bacterial Toxins
Clinical Significance of Antibiotic Resistance
Microbiota Modulation by Antibiotics

