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Sec2 is a highly efficient exchange factor for the Rab protein Sec4.

Aymelt Itzen1, Alexey Rak, Roger S Goody

  • 1Department of Physical Biochemistry, Max-Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Journal of Molecular Biology
|December 1, 2006
PubMed
Summary

Sec2 is a highly active guanine nucleotide exchange factor for yeast Rab-protein Sec4, crucial for exocytosis. Its rapid GDP displacement kinetics significantly surpass other known Rab exchange factors, highlighting its unique efficiency in vesicular transport regulation.

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