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Published on: October 11, 2024
Bilateral and unilateral movement training on upper limb function in chronic stroke patients: A TMS study
Jeffery J Summers1, Florian A Kagerer, Michael I Garry
1Human Motor Laboratory, School of Psychology, University of Tasmania, Australia. Jeff.Summers@utas.edu.au
Journal of the Neurological Sciences
|December 1, 2006
Summary
Bilateral arm training improved upper limb function and reduced movement time in chronic stroke patients more than unilateral training. Some patients showed changes in brain activity in the non-affected hemisphere.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Motor Control
Background:
- Activity-dependent interventions aid upper limb recovery in chronic stroke survivors.
- Comparing unilateral and bilateral movement training is crucial for optimizing rehabilitation.
Purpose of the Study:
- To compare neurophysiological and behavioral changes between unilateral and bilateral upper limb training in chronic stroke patients.
- To evaluate the effectiveness of bilateral training for motor function recovery.
Main Methods:
- Twelve chronic stroke patients underwent six daily practice sessions of a dowel placement task.
- Participants were randomly assigned to either unilateral (impaired arm only) or bilateral (synchronous arm movement) training.
- Assessments included kinematic measurements, functional tests, and transcranial magnetic stimulation (TMS) of cortical hemispheres.
Main Results:
- Bilateral training led to reduced impaired limb movement time and enhanced upper limb function compared to unilateral training.
- Some patients in the bilateral group exhibited changes in cortical representation in the non-affected hemisphere.
- Functional improvements were observed following the intervention sessions.
Conclusions:
- Short-term bilateral training may effectively enhance upper limb motor function in chronic stroke patients.
- Bilateral training shows potential for greater functional gains than unilateral training.
- Neuroplastic changes in the non-affected hemisphere might contribute to motor recovery.

