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Updated: Jul 18, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

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Malignant uveitis masking a lymphocytic lymphoma.

María José Molina Garrido¹, Carmen Guillén Ponce, Clara María Escolano Hortelano

¹Department of Oncology. General Universitary Hospital from Elche, Alicante. Spain. mjmolinagarrido@hotmail.com

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|December 1, 2006

Summary

B-cell lymphocytic lymphoma can manifest as bilateral posterior uveitis, a rare presentation. Diagnosis requires a systematic evaluation, including biopsy, to identify the underlying cause of this vision-threatening condition.

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Area of Science:

Ophthalmology
Oncology
Pathology

Background:

Posterior bilateral uveitis can stem from diverse etiologies, with diagnosis sometimes challenging.
Pericardial effusion, while often diagnosable, can present obscure causes even after thorough investigation.

Observation:

A case report details a patient with B-cell lymphocytic lymphoma presenting unusually as bilateral posterior uveitis.
The diagnostic process involved a systematic evaluation and biopsy for definitive diagnosis.

Findings:

Biopsy confirmed B-cell lymphocytic lymphoma as the cause of bilateral posterior uveitis.
Multiple diagnostic tests played a crucial role in confirming the diagnosis.

Implications:

This case highlights the importance of considering hematologic malignancies in the differential diagnosis of unexplained bilateral posterior uveitis.
Early and accurate diagnosis through biopsy and comprehensive testing is vital for appropriate management and improved patient outcomes.