Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MiST: a microbial signal transduction database.

Luke E Ulrich1, Igor B Zhulin

  • 1Joint Institute for Computational Sciences, The University of Tennessee-Oak Ridge National Laboratory, Oak Ridge, TN 37831-6173, USA. ulrichle@ornl.gov

Nucleic Acids Research
|December 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The last bacterial common ancestor encoded a complex flagellum.

bioRxiv : the preprint server for biology·2026
Same author

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization.

The FEBS journal·2026
Same author

A bacterial NO-binding sensor domain evolved through acquisition of a cytochrome-derived c-type heme-binding motif.

bioRxiv : the preprint server for biology·2026
Same author

The PAS domain of the polarly localized histidine kinase FlrB in <i>Vibrio cholerae</i> controls class III flagellar transcription and contributes to intestinal colonization.

mBio·2025
Same author

Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate.

Genome biology·2025
Same author

Specificities of chemosensory receptors in the human gut microbiota.

Proceedings of the National Academy of Sciences of the United States of America·2025

The microbial signal transduction (MiST) database identifies bacterial and archaeal signaling proteins. This comprehensive resource aids in understanding cellular activities across microbial genomes.

Area of Science:

  • Microbiology
  • Bioinformatics
  • Molecular Biology

Background:

  • Signal transduction pathways regulate crucial cellular activities in response to stimuli.
  • Identifying signal transduction proteins is challenging due to sequence variability and domain shuffling, leading to incomplete database annotations.

Purpose of the Study:

  • To develop a comprehensive database of microbial signal transduction proteins.
  • To provide an accessible platform for exploring and analyzing these proteins in bacterial and archaeal genomes.

Main Methods:

  • Systematic identification of two- and one-component proteins using domain profile searches.
  • Inclusion of data from 365 completely sequenced bacterial and archaeal genomes.
  • Development of a user-friendly website with advanced querying and visualization tools.

Related Experiment Videos

Main Results:

  • Identification of 69,270 signal transduction proteins across 365 microbial genomes.
  • Creation of the microbial signal transduction (MiST) database.
  • Implementation of features for sequence retrieval, domain architecture visualization, and cross-species comparison.

Conclusions:

  • The MiST database offers a unique, up-to-date catalog of microbial signaling proteins.
  • This resource facilitates research into microbial signal transduction mechanisms and cellular functions.
  • MiST supports ongoing discovery by regularly incorporating new genomic data.