Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MINT: the Molecular INTeraction database.

Andrew Chatr-aryamontri1, Arnaud Ceol, Luisa Montecchi Palazzi

  • 1Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.

Nucleic Acids Research
|December 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isw2-mediated chromatin remodeling governs antifungal tolerance and heteroresistance in Candida albicans.

npj antimicrobials and resistance·2026
Same author

MDM2 Drives Proteasome Inhibitor Resistance and Represents a TP53-Independent Therapeutic Vulnerability in Multiple Myeloma.

Cells·2026
Same author

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

bioRxiv : the preprint server for biology·2026
Same author

CRISPR-based chemogenomic profiling reveals redox vulnerabilities to epigallocatechin-3-gallate and green tea polyphenol extract.

Redox biology·2026
Same author

Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts.

Frontiers in cell and developmental biology·2025
Same author

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

bioRxiv : the preprint server for biology·2025
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Epigenetic landscape of synthetic human centromere core regions: CENP-A assembly and euchromatic modifications interdependently antagonize heterochromatin accumulation.

Nucleic acids research·2026
Same journal

MAPK/ERK signaling regulates H3K9me3 heterochromatin reorganization to confer mesendoderm developmental competence.

Nucleic acids research·2026
See all related articles

The Molecular INTeraction database (MINT) now offers enhanced protein interaction data with over 95,000 curated physical interactions. This updated resource features a remodeled structure for efficient data exploration and includes HomoMINT for human protein interactions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • The Molecular INTeraction database (MINT) curates molecular interactions (MIs) from peer-reviewed literature.
  • Current curation efforts focus exclusively on physical protein-protein interactions, excluding genetic or computationally inferred data.

Purpose of the Study:

  • To present a significantly revised version of the MINT database with an improved structure and richer annotations.
  • To expand the database's scope by integrating HomoMINT for human protein interactions.

Main Methods:

  • Extraction of experimental details from published research to curate molecular interactions.
  • Remodeling of the database structure for enhanced data exploration and analysis.
  • Integration of HomoMINT, a resource for human protein interactions derived from ortholog studies.

Related Experiment Videos

Main Results:

  • The MINT database now contains over 95,000 curated physical protein interactions.
  • The revised database structure facilitates more efficient data exploration and analysis.
  • HomoMINT has been integrated, providing data on human protein interactions.

Conclusions:

  • The updated MINT database offers a robust and expanded resource for studying physical protein interactions.
  • The integration of HomoMINT enhances its utility for human molecular interaction research.
  • The freely accessible dataset supports diverse research needs through web and FTP interfaces.