Related Experiment Video

Updated: Jul 18, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Intracerebral hemorrhages in CADASIL

Jay Chol Choi1, Sa-Yoon Kang, Ji-Hoon Kang

  • 1Department of Neurology, Cheju National University Hospital, 154 Samdo 2-dong, Jeju-si, Jeju-do, 690-716, Korea. iguazzu@hanmail.net

Neurology
|December 1, 2006
PubMed

Insights

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients with cerebral microbleeds face a higher risk of intracerebral hemorrhage. This study found 25% of symptomatic CADASIL patients experienced ICH, linked to microbleed presence.

Area of Science:

  • Neurology
  • Genetics
  • Vascular Medicine

Background:

  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare genetic disorder affecting small blood vessels in the brain.
  • Intracerebral hemorrhage (ICH) is infrequently reported in CADASIL patients.
  • Cerebral microbleeds (CMBs) are common in CADASIL (31-69%) and are known predictors of ICH risk.

Purpose of the Study:

  • To investigate the occurrence and predictors of intracerebral hemorrhage (ICH) in symptomatic patients with CADASIL.
  • To determine the relationship between cerebral microbleeds (CMBs) and the development of ICH in CADASIL.

Main Methods:

  • Retrospective analysis of symptomatic patients diagnosed with CADASIL.
  • Review of neuroimaging data to identify and quantify ICH and CMBs.
  • Statistical analysis to assess the correlation between CMBs and ICH incidence.

Main Results:

  • Intracerebral hemorrhage (ICH) was present in 25% of symptomatic CADASIL patients studied.
  • A significant association was found between the number of cerebral microbleeds (CMBs) and the development of ICH.
  • CMBs appear to be a key factor in predicting ICH risk in this population.

Conclusions:

  • Symptomatic CADASIL patients have a notable incidence of ICH, contrary to previous sporadic reports.
  • The presence and number of CMBs are strongly correlated with ICH development in CADASIL.
  • Monitoring CMBs may be crucial for assessing ICH risk in individuals with CADASIL.

More Related Videos

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage07:03

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

Published on: January 17, 2013

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...