Related Experiment Video

Updated: Jul 18, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Pleiotropic effects of the non-calcium phosphate binder sevelamer

I G Nikolov1, N Joki, J Maizel

  • 1Inserm Unit 507, Necker Hospital, University of Paris V, Paris, France.

Kidney International. Supplement
|December 1, 2006
PubMed

Insights

Chronic kidney disease (CKD) patients face rising adverse outcomes, especially cardiovascular mortality. Sevelamer hydrochloride effectively controls hyperphosphatemia without calcium overload, offering additional benefits like lipid correction.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) is a growing global health concern.
  • Cardiovascular mortality is significantly increased in CKD patients.
  • Hyperphosphatemia is a common and serious complication in advanced CKD.

Purpose of the Study:

  • To evaluate sevelamer hydrochloride as a phosphate binder in CKD patients.
  • To assess the efficacy of sevelamer hydrochloride in managing hyperphosphatemia.
  • To explore potential pleiotropic effects of sevelamer hydrochloride beyond phosphate control.

Main Methods:

  • Clinical studies and experimental research were reviewed.
  • Efficacy of sevelamer hydrochloride was compared to calcium-based phosphate binders.
  • Analysis included effects on phosphate levels, calcium load, lipid profiles, and uremic toxin clearance.

Main Results:

  • Sevelamer hydrochloride effectively controls hyperphosphatemia in CKD.
  • Unlike calcium-based binders, sevelamer does not increase calcium load.
  • Sevelamer hydrochloride demonstrates pleiotropic effects, including lipid normalization and uremic toxin reduction.

Conclusions:

  • Sevelamer hydrochloride is a safe and effective treatment for hyperphosphatemia in CKD.
  • Its non-calcium-based formulation avoids calcium overload risks.
  • Sevelamer offers additional cardiovascular and renal protective benefits through its pleiotropic actions.

More Related Videos

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...