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Related Experiment Videos

Specific decrease in liver insulin-like growth factor-I and brain insulin-like growth factor-II gene expression in

D S Straus1, C D Takemoto

  • 1Biomedical Sciences Division, University of California, Riverside 92521-0121.

The Journal of Nutrition
|August 1, 1991
PubMed
Summary

Dietary energy restriction in rats significantly impacts growth and key growth factors. Energy restriction reduced insulin-like growth factor (IGF)-I and IGF-II levels and altered IGF binding protein-2 (IGFBP-2) gene expression.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Molecular Biology

Background:

  • Growth is influenced by nutrient availability, particularly dietary energy.
  • Insulin-like growth factors (IGFs) play crucial roles in growth and development.
  • Differential regulation of IGFs and their binding proteins by energy intake is not fully understood.

Purpose of the Study:

  • To investigate the effects of controlled dietary energy restriction on growth and gene expression of IGF-I, IGF-II, and IGFBP-2 in rats.
  • To compare the molecular responses to energy restriction versus protein restriction.

Main Methods:

  • Male rats were fed diets with varying energy levels (100% to 50% of ad libitum intake) while maintaining high protein.
  • Serum levels of IGF-I and hepatic IGF-I mRNA were quantified.

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  • Gene expression of IGF-II in the brain and IGFBP-2 in the liver and brain was analyzed.

    • Main Results:

    • Growth rate was directly proportional to dietary energy intake.
    • Serum IGF-I and hepatic IGF-I mRNA levels decreased with energy restriction.
    • Brain IGF-II mRNA decreased significantly at the lowest energy intake.
    • Hepatic IGFBP-2 gene expression increased, while brain IGFBP-2 expression remained unchanged.

    Conclusions:

    • Dietary energy restriction specifically alters IGF-I, IGF-II, and IGFBP-2 gene expression in a tissue-dependent manner.
    • Energy restriction affects growth regulation differently than protein restriction, particularly concerning albumin mRNA.
    • These findings highlight the intricate relationship between energy availability and the IGF system in regulating growth.