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Updated: Jul 18, 2026
09:54
Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly)
R Galeazzi1, E Marcucci, G Martelli
1Dipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche, Ancona, Italy.
Amino Acids
|December 1, 2006
Abstract:
The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z(2))-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
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