Related Experiment Video
Updated: Jul 18, 2026

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
Published on: October 13, 2022
Regulation of apoptosis by protein S-nitrosylation
1Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A. joan.mannick@umassmed.edu
Abstract:
S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals.
Related Concept Videos
The Intrinsic Apoptotic Pathway
Regulation of the Unfolded Protein Response
Apoptosis
The Extrinsic Apoptotic Pathway
Caspases
Regulation of Nuclear Protein Sorting

