Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
The Bronchial Tree01:23

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anthracofibrosis: an under-recognised mimic of malignancy and tuberculosis in a migrant population.

Internal medicine journal·2026
Same author

Comparing Catheters to Fistulas in Older Patients Starting Hemodialysis (ACCESS HD).

Journal of the American Society of Nephrology : JASN·2026
Same author

Low-Dose Rivaroxaban and Cardiovascular Events in Advanced Kidney Disease: The TRACK Randomized Clinical Trial.

JAMA·2026
Same author

Implications of race-neutral equations on interpretation of lung function in Australia.

Internal medicine journal·2026
Same author

Current practices of SGLT2 inhibitor use and ketone monitoring in intensive care units: A multicentre observational study.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine·2026
Same author

Topical treatments and photodynamic therapy for actinic keratosis of the face and scalp.

The Cochrane database of systematic reviews·2026

Related Experiment Videos

Outcome in adult bronchiectasis.

Paul T King1, Stephen R Holdsworth, Nicholas J Freezer

  • 1Department of Respiratory Medicine, Monash Medical Centre, 246 Clayton Rd., Clayton, Melbourne, Victoria, Australia. Paul.King@med.monash.edu.au

COPD
|December 2, 2006
PubMed
Summary

Adult bronchiectasis outcomes show persistent symptoms and a significant decline in forced expiratory volume in 1 second (FEV1) over an 8-year follow-up. This study highlights the progressive nature of the disease in adults.

Related Experiment Videos

Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Respiratory Diseases

Background:

  • Long-term outcomes in adult bronchiectasis are poorly understood.
  • Prospective studies are lacking, necessitating further research into disease progression.

Purpose of the Study:

  • To assess the long-term clinical outcomes and spirometric changes in adult patients with bronchiectasis.
  • To evaluate symptom progression and lung function decline over an extended follow-up period.

Main Methods:

  • A cohort of 101 adult bronchiectasis patients (33 male, 68 female) underwent initial clinical assessment and spirometry.
  • Patients received standardized treatment and were followed prospectively for a minimum of 2 years (average 8.0 +/- 4.9 years).
  • Repeat assessments focused on symptoms and forced expiratory volume in 1 second (FEV1) compared to baseline.

Main Results:

  • Patients experienced persistent symptoms, with dyspnea and sputum volume worsening over time.
  • A significant decline in FEV1 was observed, averaging a loss of 49 ml per year.
  • The study cohort consisted of non-smokers, with 84% having idiopathic bronchiectasis.

Conclusions:

  • Adult bronchiectasis is associated with persistent symptoms and progressive lung function decline.
  • Long-term follow-up reveals worsening dyspnea and sputum production.
  • Significant annual loss of FEV1 indicates disease progression in this adult cohort.