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Related Experiment Videos

Nuclear receptor structure: implications for function.

David L Bain1, Aaron F Heneghan, Keith D Connaghan-Jones

  • 1Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. David.Bain@UCHSC.edu

Annual Review of Physiology
|December 2, 2006
PubMed
Summary
This summary is machine-generated.

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Nuclear receptors are proteins that regulate gene networks in response to small molecules. This review details their structure, focusing on ligand-binding and DNA-binding domains, and the human progesterone receptor.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Nuclear receptors are key regulators of eukaryotic gene expression, mediating cellular responses to small lipophilic molecules like hormones.
  • These ligand-activated transcription factors control complex gene networks essential for reproductive, developmental, and metabolic processes.

Purpose of the Study:

  • To review the structure and structural properties of nuclear receptors.
  • To highlight the ligand-binding and DNA-binding domains, and the less understood N-terminal regions.
  • To examine the human progesterone receptor structure to illustrate allosteric interdependence.

Main Methods:

  • Literature review focusing on structural biology of nuclear receptors.
  • Detailed analysis of existing structural data for ligand-binding and DNA-binding domains.

Related Experiment Videos

  • Case study on the human progesterone receptor structure.

    • Main Results:

    • Nuclear receptors possess distinct structural domains (ligand-binding, DNA-binding, N-terminal) that dictate their function.
    • The human progesterone receptor structure exemplifies allosteric interactions between receptor subunits.
    • Understanding these structural properties is crucial for deciphering nuclear receptor mechanisms.

    Conclusions:

    • A comprehensive understanding of nuclear receptor structure, including domain interplay, is vital for elucidating their regulatory roles.
    • Further research into the largely unstructured N-terminal regions will enhance mechanistic insights.
    • This structural perspective supports the development of quantitative models for nuclear receptor function.