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Testosterone: use, misuse and abuse.

David J Handelsman1

  • 1ANZAC Research Institute, Concord Hospital, Sydney, NSW, Australia. djh@anzac.edu.au

The Medical Journal of Australia
|December 2, 2006
PubMed
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Testosterone therapy is effective for androgen deficiency but is often misused for unproven conditions like "andropause." Androgen abuse in sports and for cosmetic purposes is also a concern, while diagnosis of deficiency in young men remains low.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Men's Health

Background:

  • Testosterone therapy has a long history of efficacy and safety for androgen replacement.
  • Androgens are used in pharmacological androgen therapy (PAT) for effects on marrow, muscle, and bone.
  • While newer drugs emerge, androgens remain cost-effective for established uses.

Purpose of the Study:

  • To review the established roles of testosterone therapy.
  • To highlight issues of androgen misuse and abuse.
  • To address the underdiagnosis of androgen deficiency in younger men.

Main Methods:

  • Literature review of testosterone and androgen use.
  • Analysis of androgen misuse for unproven indications (e.g., "andropause").
  • Examination of androgen abuse in sports and non-medical contexts.

Related Experiment Videos

Main Results:

  • Testosterone is effective for androgen deficiency but subject to misuse and abuse.
  • Androgen misuse is rising for conditions like male aging.
  • Androgen abuse occurs in sports, bodybuilding, and for cosmetic/recreational reasons.
  • Classical androgen deficiency in younger men is frequently undiagnosed.

Conclusions:

  • Testosterone remains a valuable therapeutic agent when appropriately prescribed.
  • Addressing androgen misuse and abuse requires careful monitoring and education.
  • Improving the diagnosis of androgen deficiency in young men is crucial.