Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclodextrins and their pharmaceutical applications.

Thorsteinn Loftsson1, Dominique Duchêne

  • 1Faculty of Pharmacy, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland. thorstlo@hi.is

International Journal of Pharmaceutics
|December 2, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chitosan-coated cyclodextrin-based niosomes enable enhanced nose-to-brain delivery of rivastigmine and asiaticoside for Alzheimer's disease.

International journal of biological macromolecules·2026
Same author

Cyclodextrin-Based Niosomal Delivery of Imatinib against A549 Nonsmall Cell Lung Cancer Cells.

ACS omega·2026
Same author

Cyclodextrin-based formulations for pediatric patients: pharmaceutical prospectives and toxicological evaluation.

The Journal of pharmacy and pharmacology·2025
Same author

The Chemical Stability Characterization and Kinetics of Statins in Aqueous Cyclodextrin Ocular Preparations: A Formulation Perspective.

Pharmaceutics·2025
Same author

A comprehensive nomenclature system for cyclodextrins.

Carbohydrate polymers·2025
Same author

A recent update of water-soluble polymers in cyclodextrin-based formulations for mucosal drug delivery.

Carbohydrate polymers·2025
Same journal

Artificial intelligence and CRISPR-based approaches for targeted delivery of bacteriophages.

International journal of pharmaceutics·2026
Same journal

A "three-in-one" nose-to-brain delivery strategy: intranasal vancomycin spray achieves simultaneous clearance of pneumococcal colonization, bacteremia, and meningitis.

International journal of pharmaceutics·2026
Same journal

10-Hydroxy-2-decenoic acid /matrine deep eutectic solvent encapsulated in hyalurosomes for enhanced transdermal delivery and antioxidant efficacy.

International journal of pharmaceutics·2026
Same journal

Dual-trigger hyaluronic acid nanoprodrug incorporating a 2-nitrobenzenesulfonyl linker for CD44-targeted and glutathione-responsive drug delivery.

International journal of pharmaceutics·2026
Same journal

Polymeric mixed micellar nanogel enhances dermal delivery and therapeutic efficacy of tofacitinib citrate.

International journal of pharmaceutics·2026
Same journal

Localized gold nanoparticles-mediated photothermal therapy for head and neck cancer: in vivo proof-of-concept.

International journal of pharmaceutics·2026
See all related articles

Cyclodextrins, cyclic oligosaccharides discovered in 1891, have evolved into crucial pharmaceutical excipients. Their unique ability to form inclusion complexes enhances drug solubility and stability, offering unexplored potential.

Area of Science:

  • Carbohydrate Chemistry
  • Supramolecular Chemistry
  • Pharmaceutical Sciences

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch, first described in the late 19th century.
  • Pioneering research by Schardinger, Freudenberg, and Cramer elucidated their structure and inclusion complex formation.
  • Early 20th-century work established the fundamental physicochemical properties of CDs, including drug solubilization and stabilization.

Observation:

  • The ability of cyclodextrins to form inclusion complexes was a key discovery, enabling molecular encapsulation.
  • By the 1950s, essential characteristics like drug solubilization and stabilization were recognized.
  • The development of pure, pharmaceutical-grade cyclodextrins occurred approximately 25 years after initial patent filings.

Findings:

Related Experiment Videos

  • Cyclodextrins are cyclic oligosaccharides composed of glucose units.
  • They possess the unique ability to form non-covalent inclusion complexes with various guest molecules.
  • Their physicochemical properties allow for enhanced solubility and stability of encapsulated substances, particularly drugs.

Implications:

  • The first cyclodextrin-containing pharmaceutical product was marketed in Japan, followed by European and US introductions.
  • Cyclodextrin technology continues to advance, with ongoing development of novel applications.
  • Despite over a century of research, cyclodextrins remain considered novel excipients with significant unexplored potential in drug delivery and formulation.