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Total antioxidant/oxidant status in meningism and meningitis

Ali Aycicek1, Akin Iscan, Ozcan Erel

  • 1Pediatric Service, Sanliurfa Children's Hospital, Sanliurfa, Turkey. ali_aycicek@yahoo.com.tr

Pediatric Neurology
|December 2, 2006
PubMed

Insights

Children with meningismus or bacterial meningitis show altered antioxidant and oxidant levels in serum and cerebrospinal fluid. Meningitis cases exhibit distinct cerebrospinal fluid oxidant status compared to meningismus.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Neurology

Background:

  • Meningismus and acute bacterial meningitis present with fever and meningeal signs in children.
  • Understanding the oxidative stress markers in these conditions is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the serum and cerebrospinal fluid antioxidant/oxidant status in children with meningismus and acute bacterial meningitis.
  • To compare these oxidative stress markers between patients and healthy controls.

Main Methods:

  • Measured antioxidant markers (ascorbic acid, albumin, thiol, uric acid, bilirubin, TAC, catalase, ceruloplasmin) and oxidant markers (LPO, TOS) in serum and CSF.
  • Included 23 children with meningismus, 31 with acute bacterial meningitis, and 29 healthy controls.
  • Utilized statistical analysis to compare marker levels between groups.

Main Results:

  • Serum antioxidant status was lower, and oxidant status higher in both meningismus and meningitis groups compared to controls (P < 0.001).
  • Cerebrospinal fluid oxidant status was lower in the meningitis group than in the meningismus group (P < 0.05).
  • Serum oxidant status was elevated in both patient groups, while CSF oxidant status differed between meningismus and meningitis.

Conclusions:

  • Children with meningismus and acute bacterial meningitis exhibit significant alterations in serum antioxidant and oxidant profiles.
  • Cerebrospinal fluid oxidant status may serve as a differentiating marker between meningismus and acute bacterial meningitis.
  • These findings highlight the role of oxidative stress in pediatric meningitis and related conditions.

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