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Related Experiment Video

Updated: Jul 18, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Oncogenic inflammation and autoimmune disease.

Laurence C Eisenlohr¹, Jay L Rothstein

¹Departments of Microbiology/Immunology and Otolaryngology-HNS, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

Autoimmunity Reviews

|December 2, 2006

Summary

Autoimmune diseases may involve target organs actively contributing through self-produced co-stimulatory factors. Newly transformed cells within these organs can release pro-inflammatory signals, prolonging immune responses.

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Area of Science:

Immunology and Autoimmunity
Cellular Signaling in Disease

Background:

Existing models for autoimmune disease induction and perpetuation lack human-specific validation.
The precise mechanisms driving human autoimmune conditions remain incompletely understood.

Purpose of the Study:

To propose a novel mechanism for autoimmune disease pathogenesis involving the target organ's active role.
To investigate the contribution of endogenously produced co-stimulatory factors in sustaining autoimmune responses.

Main Methods:

Conceptual review and synthesis of existing evidence.
Hypothesis generation based on cellular and molecular immunology principles.

Main Results:

Proposed that target organs actively participate in autoimmune disease via endogenous co-stimulatory factors.
Identified newly transformed cells within target organs as a potential source of these pro-inflammatory signals.
These signals may lead to prolonged antigen presentation and lymphocyte activation.

Conclusions:

The target organ's active participation, driven by endogenous signaling from transformed cells, is a key aspect of autoimmune disease.
This mechanism offers a new perspective on the perpetuation of autoimmune conditions in humans.