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Related Experiment Videos

Does interictal spiking change prior to seizures?

A Katz1, D A Marks, G McCarthy

  • 1Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.

Electroencephalography and Clinical Neurophysiology
|August 1, 1991
PubMed
Summary

In intractable epilepsy, spiking activity did not change in the 5 minutes before seizures. This study analyzed preictal changes in spiking for epilepsy surgery evaluations.

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Area of Science:

  • Neurology
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Intractable epilepsy requires surgical evaluation.
  • Preictal changes in epileptic spiking are of clinical interest.
  • Understanding preictal patterns aids epilepsy surgery planning.

Purpose of the Study:

  • To investigate preictal changes in epileptic spiking.
  • To determine if spiking frequency alters in the minutes preceding seizures.
  • To assess the utility of preictal spiking for localizing seizure onset.

Main Methods:

  • Continuous EEG monitoring in 10 patients undergoing epilepsy surgery evaluation.
  • Computerized detection and counting of interictal spikes.
  • Analysis of spiking activity in 0-5, 5-10, and 0-60 minute preictal epochs.

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  • Statistical comparison of spiking rates during different preictal periods.

    • Main Results:

    • No significant difference in total spiking activity across preictal epochs (0-5, 5-10, 0-60 min).
    • No significant difference in spiking originating from the seizure onset channel in localized seizures.
    • Findings held true during epochs of consistent arousal states (awake or sleep stage II).

    Conclusions:

    • Epileptic spiking does not significantly change in the 5 minutes before seizures.
    • Short-term preictal spiking patterns are not reliable indicators of impending seizures.
    • These findings suggest limited value of immediate preictal spiking for surgical localization.