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n-3 fatty acids and acute-phase proteins.

E Ernst1, T Saradeth, G Achhammer

  • 1Department of Physical Medicine, LM University, Munich.

European Journal of Clinical Investigation
|February 1, 1991
PubMed
Summary

n-3 fatty acids supplementation reduced baseline levels of certain acute-phase proteins. Exercise altered the response pattern of these proteins, with n-3 fatty acids potentially prolonging their increase.

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Area of Science:

  • Exercise Physiology
  • Nutritional Biochemistry

Background:

  • Acute-phase proteins (APPs) are key indicators of inflammation and physiological stress.
  • n-3 fatty acids are known for their anti-inflammatory properties.
  • The impact of n-3 fatty acids on the acute-phase response to exercise is not fully understood.

Purpose of the Study:

  • To investigate the effects of n-3 fatty acid supplementation on baseline levels of APPs.
  • To examine how n-3 fatty acids influence the body's acute-phase protein response to strenuous exercise.

Main Methods:

  • Healthy male volunteers underwent bicycle ergometry.
  • Supplementation involved 3 weeks of highly purified n-3 fatty acids (1.75 g EPA, 1.05 g DHA daily).
  • Measurements of 8 APPs (IgM, C4, haptoglobin, CRP, α2-macroglobulin, ceruloplasmin, fibrinogen, α1-glycoprotein) were taken pre-exercise, immediately post-exercise, and at 24 and 72 hours post-exercise.

Main Results:

  • n-3 supplementation led to significantly lower pre-exercise levels of immunoglobulin M (IgM) and alpha 2-macroglobulin (α2-macroglobulin).
  • Exercise induced a discernible acute-phase reaction, observed both with and without n-3 supplementation.
  • n-3 fatty acids appeared to alter the kinetics of the APP response, with a numerically larger and longer-lasting increase in fibrinogen and alpha 1-glycoprotein.

Conclusions:

  • n-3 fatty acids may lower baseline concentrations of specific acute-phase proteins.
  • Supplementation with n-3 fatty acids modifies the pattern and duration of the acute-phase protein response following acute exercise.

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