Related Experiment Video
Updated: Jul 18, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
Published on: May 31, 2011
MotifScorer: using a compendium of microarrays to identify regulatory motifs
Matteo Brilli1, Renato Fani, Pietro Lió
1Dipartimento di Biologia Animale e Genetica, via Romana 17, 50125 Firenze, Italy.
Unlabelled:
We describe MotifScorer, a program for systematic genome-wide identification of transcription sites. The program uses a compendium of gene expression microarrays and implements state-of-art partial least squares (PLSs) based regression and stepwise regression procedures. Candidate motifs from the upstream sequences of groups of co-regulated genes are identified and assigned a score using genomic background models and available motif finding tools. The use of a large library of expression data allows statistical comparative analysis of the specificity of motifs identified in different conditions.
Availability:
MotifScorer, which is written in Java and Matlab, manual and example files are available from the authors.
More Related Videos
Related Concept Videos
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
DNA Microarrays
Cis-regulatory Sequences
Cis-regulatory Sequences
Regulation of Expression at Multiple Steps
Cooperative Binding of Transcription Regulators

