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Genotype-corrected reference values for serum angiotensin-converting enzyme.

H Biller1, G Zissel, B Ruprecht

  • 1Department of Pneumology, Medical Center, University of Freiburg, Killianstr. 5, D-79104 Freiburg, Germany.

The European Respiratory Journal
|December 2, 2006
PubMed
Summary
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The angiotensin-converting enzyme (ACE) gene

Area of Science:

  • Genetics and Molecular Biology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • The deletion (D)/insertion (I) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene significantly influences serum ACE levels in Caucasians.
  • Existing reference ranges for serum ACE may not adequately account for genetic variations.

Purpose of the Study:

  • To establish new, genotype-corrected normal ranges for serum ACE levels in a central European population.
  • To assess the impact of ACE gene polymorphism on serum ACE levels in this cohort.

Main Methods:

  • 159 healthy Caucasian volunteers underwent medical examination and blood donation.
  • ACE genotypes were determined using Polymerase Chain Reaction (PCR).
  • Serum ACE levels were measured using two distinct kinetic assays.

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Main Results:

  • ACE genotype distribution adhered to Hardy-Weinberg equilibrium.
  • Significant correlation observed between serum ACE levels and ACE genotypes (D/D highest, I/I lowest).
  • Two different assay kits yielded significantly correlated results despite differing absolute values.

Conclusions:

  • The study recommends implementing new, genotype-specific reference values for serum ACE levels.
  • Genotype-corrected ranges can enhance the sensitivity and specificity of ACE testing, particularly in sarcoidosis follow-up.