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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Related Experiment Video

Updated: Apr 13, 2026

Identification of protein complexes with quantitative proteomics in S. cerevisiae
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Identification of protein complexes with quantitative proteomics in S. cerevisiae

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Functional and quantitative proteomics using SILAC.

Matthias Mann1

  • 1Department of Proteomics and Signal Transduction, Max-Planck Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. mmann@biochem.mpg.de

Nature Reviews. Molecular Cell Biology
|December 2, 2006
PubMed
Summary
This summary is machine-generated.

Stable-isotope labelling by amino acids in cell culture (SILAC) is a powerful quantitative proteomics method. It enhances protein interaction studies and reveals proteome kinetics and signaling pathway dynamics.

Area of Science:

  • Proteomics
  • Biochemistry
  • Cellular Biology

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