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Updated: Jul 18, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
The emerging role of cannabinoid neuromodulators in symptom management
Mellar Davis1, Vincent Maida, Paul Daeninck
1The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. davism6@ccf.org
Introduction:
The cannabinoids nabilone (Cesamet) and dronabinol (Marinol) are indicated for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients who have failed to respond adequately to conventional antiemetic therapy.
Discussion:
The endocannabinoid (CB) system interacts with numerous other systems and pharmaceutical cannabinoids target ubiquitous CB1 and CB2 receptors in the central nervous system and periphery, relieving nausea and vomiting and pain.
Summary:
The benefits of this novel class of medications in cancer may extend beyond CINV, as indicated by data from preclinical studies and animal models.
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