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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Hirschsprung's disease in adults
G I Vorobyov1, S I Achkasov, O M Biryukov
1The State Scientific Centre of Coloproctology, Moscow, Russia.
Acta Chirurgica Iugoslavica
|December 5, 2006
Insights
Hirschsprung
Area of Science:
- Pediatric surgery
- Gastroenterology
- Developmental biology
Background:
- Hirschsprung's disease is a congenital hindgut malformation.
- It is characterized by the absence of ganglion cells in the intestinal plexuses.
- This absence leads to megacolon and functional obstruction.
Purpose of the Study:
- To provide an overview of Hirschsprung's disease.
- To highlight diagnostic and treatment advancements.
- To emphasize the successful resolution of associated pediatric clinical problems.
Main Methods:
- Review of existing pediatric clinical data.
- Analysis of diagnostic methodologies.
- Evaluation of established treatment protocols.
Main Results:
- Diagnosis and treatment of Hirschsprung's disease have seen significant progress.
- Pediatricians have successfully resolved many challenges related to this condition.
- Improved outcomes in affected children are evident.
Conclusions:
- Hirschsprung's disease, a congenital condition, is effectively managed in pediatric settings.
- Advances in pediatric care have led to successful diagnosis and treatment.
- The prognosis for children with Hirschsprung's disease has improved considerably.
Abstract:
Hirschsprung's disease is the malformation of the hindgut characterised by the absence of intramural ganglion cells in the submucosal and myenteric plexuses and manifested by megacolon. Congenital character of this disease stipulates its belonging in general to the scope of activity of the pediatric clinics. Thanks to the progress of the pediatricians problems of diagnosis and treatment of Hirschsprung's disease have been successfully resolved.
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