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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Hormones and Bone Tissue

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Graves Disease II: Pathophysiology01:24

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Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
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Related Experiment Video

Updated: Jul 18, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

[Hypocalcemia after thyroidectomy: analysis on 804 treated patients].

Mario Sianesi1, Paolo Del Rio, Maria Francesca Arcuri

  • 1Istituto di Clinica Chirurgica Generale e dei Trapianti d'Organo Università di Parma.

Annali Italiani Di Chirurgia
|December 5, 2006
PubMed
Summary

Post-thyroidectomy hypocalcemia affects over 20% of patients, often resolving within a week. Key causes include inadvertent parathyroid gland removal, ischemia, and injury during surgery.

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Last Updated: Jul 18, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

Area of Science:

  • Endocrinology
  • Surgical Oncology

Context:

  • Thyroidectomy is a common surgical procedure.
  • Hypocalcemia is a recognized complication following thyroidectomy.
  • The precise causes of post-thyroidectomy hypocalcemia require further elucidation.

Purpose:

  • To investigate the incidence and potential causes of hypocalcemia after thyroidectomy.
  • To analyze preoperative and postoperative serum calcium, ionized calcium, parathyroid hormone (PTH), and phosphate levels in patients undergoing thyroidectomy.

Summary:

  • A study of 804 patients (594 total thyroidectomy, 209 emithyroidectomy) revealed a 21.2% incidence of hypocalcemia (serum calcium < 7.5 mg/dL).
  • In most cases (90.6%), serum calcium normalized within seven days post-surgery.
  • Two patients developed permanent hypoparathyroidism at 180 days, highlighting potential long-term risks.

Impact:

  • Identifies inadvertent parathyroid gland excision, ischemia, and injury as primary contributors to hypocalcemia post-thyroidectomy.
  • Provides crucial data for surgical technique refinement and patient management strategies to mitigate hypocalcemia risk.
  • Contributes to understanding the pathophysiology and clinical course of post-thyroidectomy hypocalcemia.