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Related Experiment Video

Updated: Jul 18, 2026

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Multiple meningiomas induced by cranial irradiation.

Zacharias Volikas¹, Emmanouel M Chatzidakis, Nicolas Condilis

¹Division of Surgery, University of Thrace.

Annali Italiani Di Chirurgia

|December 5, 2006

Summary

High-dose cranial irradiation, though rarely reported, can induce multiple meningiomas. This case highlights the long-term risk of radiation-induced brain tumors in patients treated for childhood ependymoma.

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Last Updated: Jul 18, 2026

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Area of Science:

Neuro-oncology
Radiation oncology
Clinical case study

Background:

Cranial irradiation is a known risk factor for central nervous system tumors.
Meningiomas are the most common type of radiation-induced brain tumor.
While low-dose radiation-induced meningiomas are well-documented, high-dose induction is less common.

Observation:

A 25-year-old male presented with multiple meningiomas.
The patient received therapeutic high-dose irradiation for a 4th ventricle ependymoma at age 8.
This history suggests a potential link between high-dose radiation and subsequent meningioma development.

Findings:

The development of multiple meningiomas in this patient following high-dose cranial irradiation supports a causal relationship.
This case adds to the limited evidence linking therapeutic radiation doses to meningioma induction.
The latency period between irradiation and tumor diagnosis is significant.

Implications:

Reinforces the importance of long-term surveillance for CNS tumors in patients treated with cranial irradiation.
Highlights the need for further research into the risks associated with high-dose radiation therapy.
Informs clinical decision-making regarding radiation protocols and patient monitoring for secondary malignancies.