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Factors associated with hypospadias in Asian newborn babies

Jin Ho Chong1, Chee Keong Wee, Selina Kah Ying Ho

  • 1Singapore General Hospital, Outram Road, Singapore.

Journal of Perinatal Medicine
|December 5, 2006
PubMed

Insights

Hypospadias incidence is rising, particularly in Asian infants. Key risk factors include very low birth weight, small for gestational age, and maternal preeclampsia, but not preterm birth.

Area of Science:

  • Pediatric Urology
  • Neonatalogy
  • Public Health

Background:

  • Previous studies indicate an increasing trend in hypospadias incidence.
  • A link between hypospadias and poor intrauterine growth has been suggested.
  • The specific factors contributing to this association, such as birth weight or prematurity, require further investigation.

Purpose of the Study:

  • To investigate the incidence of hypospadias.
  • To examine the association between hypospadias and various risk factors.
  • To analyze trends in hypospadias over time.

Main Methods:

  • A retrospective case-control study was conducted.
  • Data was collected from infants admitted to a neonatal unit between 1999 and 2005.
  • Statistical analysis, including logistic regression, was employed to identify risk factors.

Main Results:

  • The incidence of hypospadias was 0.41% (27 out of 6538 male births).
  • A significant increasing trend in incidence was observed from 1999 to 2005.
  • Hypospadias was significantly associated with very low birth weight (VLBW), small for gestational age (SGA), and maternal preeclampsia (PET).

Conclusions:

  • Very low birth weight, SGA, and maternal preeclampsia are independent risk factors for hypospadias.
  • Hypospadias is not significantly associated with preterm birth.
  • The rising incidence of hypospadias in this Asian population suggests a potentially universal trend.
Abstract

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