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The use of fluoroquinolones in children: recent advances

Ioanna M Velissariou1

  • 1Pediatric Infectious Diseases, University of Athens, P and A Kyriakou Children's Hospital, 2nd Department of Pediatrics, Athens, Greece. jane_vel@hotmail.com

Expert Review of Anti-Infective Therapy
|December 5, 2006
PubMed

Insights

Fluoroquinolone antibiotics are increasingly considered for pediatric use due to new agents with broad-spectrum activity and improved safety. This review covers their pharmacokinetics, uses, and toxicity in children.

Area of Science:

  • Pharmacology
  • Pediatric Infectious Diseases

Background:

  • Fluoroquinolones are broad-spectrum antibiotics with excellent efficacy in adults.
  • Historically, their use in children was limited by concerns of joint toxicity.

Purpose of the Study:

  • To review the pharmacokinetics, clinical indications, and toxicity of fluoroquinolones in pediatric patients.
  • To discuss newer fluoroquinolone agents and their safety profile in pediatrics.

Main Methods:

  • Literature review of pharmacokinetic data.
  • Analysis of clinical studies on fluoroquinolone use in children.
  • Evaluation of safety and toxicity data, including joint effects.

Main Results:

  • Newer fluoroquinolones exhibit a wide antimicrobial range and reduced toxicity in pediatric populations.
  • Pharmacokinetic profiles and clinical efficacy are being established for pediatric use.
  • Careful consideration of risk-benefit is necessary, especially regarding potential joint toxicity.

Conclusions:

  • Fluoroquinolones are becoming a viable option for treating pediatric infections.
  • Emerging agents offer improved safety, expanding their pediatric application.
  • Ongoing research is crucial for optimizing fluoroquinolone use in children.

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