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Updated: Jul 18, 2026
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
High-accuracy proteome maps of human body fluids
Alexander Schmidt1, Ruedi Aebersold
1Institute for Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli-Strasse 16, CH-8093 Zurich, Switzerland.
Genome Biology
|December 5, 2006
Summary
Human body fluid proteomes offer potential for disease biomarker discovery. Recent proteomic analyses of tears, urine, and seminal plasma provide valuable datasets for identifying new biomarkers.
Area of Science:
- Biochemistry
- Proteomics
- Biomedical Science
Background:
- Human body fluid proteomes are a rich source of potential disease biomarkers.
- Identifying these biomarkers is crucial for advancing diagnostic and prognostic capabilities.
Purpose of the Study:
- To highlight the utility of human body fluid proteomes for biomarker discovery.
- To present recent large-scale proteomic analyses of tears, urine, and seminal plasma.
Main Methods:
- Utilizing advanced mass spectrometric technology for high-throughput proteomic analysis.
- Analyzing the proteomes of human tears, urine, and seminal plasma.
Main Results:
- Generated comprehensive proteomic datasets from key human body fluids.
- These datasets are suitable for extensive biomarker discovery efforts.
Conclusions:
- Large-scale proteomic analyses of human body fluids yield valuable data.
- These findings support the ongoing search for clinically relevant disease biomarkers.
