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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: Jul 18, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

Hematopoietic cells from primate embryonic stem cells.

Fei Li¹, Shi-Jiang Lu, George R Honig

¹Advanced Cell Technology, Biotech Five, Worcester, Massachusetts, USA.

Methods in Enzymology

|December 5, 2006

Summary

Nonhuman primate embryonic stem (ES) cells offer a better model for human development than mouse ES cells. Researchers developed methods for efficient differentiation into hematopoietic precursors similar to adult bone marrow cells.

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Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

Area of Science:

Developmental Biology
Stem Cell Research
Hematopoiesis

Background:

Embryonic stem (ES) cells are pluripotent cells from early embryos.
Mouse ES cells differentiate into various cell types, including hematopoietic precursors.
Mouse ES cell differentiation has limitations as a model for human development.

Purpose of the Study:

To evaluate nonhuman primate ES cells as a model for human developmental biology.
To develop efficient differentiation methods for nonhuman primate ES cells.
To generate hematopoietic precursors similar to human adult cells.

Main Methods:

Isolation and characterization of nonhuman primate ES cell lines.
Development of experimental conditions for ES cell differentiation.
Analysis of differentiated progeny for similarity to human hematopoietic precursors.

Main Results:

Nonhuman primate ES cells exhibit characteristics closer to human biology.
Developed conditions promote efficient differentiation of these cells.
Generated progeny cells show considerable similarity to adult bone marrow hematopoietic precursors.

Conclusions:

Nonhuman primate ES cells provide a valuable model for studying human hematopoiesis.
This differentiation method yields hematopoietic precursors relevant to human biology.
Advances in stem cell differentiation offer new avenues for regenerative medicine research.