Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Adult-onset Still's disease diagnosed in pregnancy.

Modern rheumatology case reports·2026

Same author

What Is Cell Stem Cell Doing to Support the Global Stem Cell Community during the COVID-19 Pandemic?

Cell stem cell·2020

Same author

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.

Biochemical and biophysical research communications·2020

Same author

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy.

Scientific reports·2019

Same author

A quantitative, multi-national and multi-stakeholder assessment of barriers to the adoption of cell therapies.

Journal of tissue engineering·2017

Same author

Neural Stem Cell Tumorigenicity and Biodistribution Assessment for Phase I Clinical Trial in Parkinson's Disease.

Scientific reports·2016

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Neural stem cells and their manipulation.

Prithi Rajan¹, Evan Snyder

¹Center for Neuroscience and Aging, Burham Institute for Medical Research, La Jolla, CA, USA.

Methods in Enzymology

|December 5, 2006

Summary

Neural stem cells (NSCs) respond to external signals, with context influencing their proliferation, survival, and differentiation. Understanding these signals aids in controlling NSC behavior for research and therapeutic applications.

Area of Science:

Neuroscience
Stem Cell Biology
Cell Signaling

Background:

Neural stem cells (NSCs) are crucial for brain development and repair.
Their biological processes, including proliferation, survival, and differentiation, are heavily influenced by extracellular signals.
The cellular response to signals is context-dependent, shaped by prior and concurrent signaling events.

Purpose of the Study:

To synthesize known signaling pathways regulating mammalian NSC behavior.
To provide a comprehensive understanding of factors controlling NSC proliferation, survival, and differentiation.
To enable more precise and reproducible manipulation of NSCs for specific outcomes.

Main Methods:

Literature review of signaling pathways in mammalian NSCs.

More Related Videos

Expansion of Embryonic and Adult Neural Stem Cells by In Utero Electroporation or Viral Stereotaxic Injection

Expansion of Embryonic and Adult Neural Stem Cells by In Utero Electroporation or Viral Stereotaxic Injection

Published on: October 6, 2012

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Jul 18, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Expansion of Embryonic and Adult Neural Stem Cells by In Utero Electroporation or Viral Stereotaxic Injection

Expansion of Embryonic and Adult Neural Stem Cells by In Utero Electroporation or Viral Stereotaxic Injection

Published on: October 6, 2012

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Synthesis of data on extracellular signals affecting NSC fate.

Analysis of in vivo and in vitro studies on NSC biology.

Main Results:

Identified key extracellular signals promoting NSC proliferation.
Summarized signals that enhance NSC survival.
Detailed signals that direct NSC differentiation.
Highlighted the context-dependent nature of signal transduction in NSCs.

Conclusions:

A thorough understanding of signaling pathways is essential for controlling NSC fate.
This knowledge facilitates the precise manipulation of NSCs for research and therapeutic purposes.
Further research into signal integration will advance regenerative medicine strategies.