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Related Experiment Video

Updated: Jul 18, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Crosslinked hydrogels for tympanic membrane repair.

Albert H Park1, Casey W Hughes, Adrienne Jackson

  • 1Division of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah 84132, USA. pcapark@ihc.com

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|December 5, 2006
PubMed
Summary

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Carbylan-GSX and Gelfoam effectively promote tympanic membrane perforation closure. This study validates Carbylan-GSX as a promising material for treating ear drum perforations in a guinea pig model.

Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Tympanic membrane perforations (TMPs) can impair hearing and require effective treatment.
  • Current protocols for TMP repair may be costly or inconvenient.
  • Developing novel biomaterials for TMP closure is an ongoing area of research.

Purpose of the Study:

  • To evaluate novel biomaterials for tympanic membrane perforation (TMP) repair.
  • To identify a less expensive and more convenient treatment protocol for TMPs.
  • To compare the efficacy of Carbylan-GSX and Gelfoam in an animal model.

Main Methods:

  • Several biomaterials were prepared and tested, including Carbylan-SX, Gelatin-DTPH-PEGDA (GX), Carbylan-S/Gelatin-DTPH (Carbylan-GSX) (injectable and sponge), Gelfoam, Epifilm, and crosslinked thiolated chondroitin sulfate (CS-DTPH-PEGDA [CS-SX]).

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Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
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Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

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Last Updated: Jul 18, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

  • Bilateral myringotomy was performed on Hartley guinea pigs, with one ear serving as a control and the other treated with a test material.
  • Closure rates and inflammatory responses were assessed.

    • Main Results:

    • Carbylan-GSX (injectable and sponge), Gelfoam with saline, and CS-SX demonstrated the shortest TMP closure times.
    • Epifilm, Carbylan, and gelatin preparations showed closure rates comparable to controls.
    • CS-SX induced a significant inflammatory reaction, unlike other materials.

    Conclusions:

    • Carbylan-GSX, in both injectable and sponge forms, is validated as an effective material for TMP closure.
    • The study supports Carbylan-GSX as a viable alternative to Gelfoam for acute TMP repair in a guinea pig model.
    • Further research may explore the clinical application of Carbylan-GSX for tympanic membrane perforations.