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Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and

Jenny C Hu1, Parrish Sadeghi, Lauren C Pinter-Brown

  • 1David Geffen School of Medicine at University of California, Los Angeles 90095, USA.

Journal of the American Academy of Dermatology
|December 5, 2006
PubMed

Insights

Epidermal growth factor receptor (EGFR) inhibitors are effective cancer treatments but often cause skin problems. Dermatologists can help manage these side effects, improving patient treatment compliance and outcomes.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Epidermal growth factor receptor (EGFR) inhibitors are increasingly used in cancer therapy due to their targeted action and improved safety over conventional chemotherapy.
  • Despite their benefits, EGFR inhibitors are associated with a rising incidence of cutaneous toxicities, causing significant patient discomfort and potentially leading to treatment non-compliance.

Purpose of the Study:

  • This review aims to outline the common skin side effects associated with EGFR inhibitor therapy.
  • It also discusses management strategies for these toxicities.

Main Methods:

  • Literature review of studies on EGFR inhibitors and their dermatologic side effects.
  • Synthesis of information on clinical presentation and management options for cutaneous toxicities.

Main Results:

  • Common cutaneous side effects include rash, dry skin, and nail changes.
  • Effective management strategies are crucial for patient well-being and treatment adherence.

Conclusions:

  • Dermatologists play a vital role in managing EGFR inhibitor-induced skin toxicities.
  • Successful management can enhance patient compliance with anti-EGFR therapy and support overall cancer treatment goals.

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